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KMID : 1140120100150030198
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Cancer Prevention Research
2010 Volume.15 No. 3 p.198 ~ p.203
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Lactic Acid Bacteria Induces Apoptosis through AMP-activated Protein Kinase in MCF-7 Breast Cancer Cells
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Lee Sol-Hwa
Park Ock-Jin
Kim Young-Min
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Abstract
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Lactic Acid Bacteria (LAB) and cultured dairy products exert effect of anti-cancer that inhibits the growth of many types of cancer, including breast cancer. Also, they exert effect of anti-metastasis that inhibits proliferation of cancer cells. AMP-activated protein kinase (AMPK) is activated by ATP depletion status such as heat shock, exercise, hypoxia, reactive oxygen species (ROS). Recent studies indicate that AMPK activation strongly suppresses cell proliferation and induces apoptosis in cancer cells. Hence, AMPK plays a critical role as a key signal in prevention of cancer. The AMPK activation is also known to be related with expression of cyclooxygenase-2 (COX-2) and mammalian target of rapamycin (mTOR). In this study, the LAB in MCF-7 breast cancer cell lines seemed to be closely related to an increase in AMPK activation. ROS generated by treatment of LAB, which induced apoptosis and inhibited proliferation of cancer cells. ROS is an upstream regulator of AMPK, and the activation of AMPK as the key element in the regulation of COX-2 and mTOR expression. Our results suggest that LAB is an effective way in controlling proliferation of breast cancer cells and apoptosis of them. Therefore, the effect of LAB will be a potent a chemotherapy in cancer.
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KEYWORD
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Lactic Acid Bacteria, AMPK, Apoptosis, MCF-7cells, ROS
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